5. Tom and Jerry
We can’t even count the amount of times Tom and Jerry have gone at it. Actually, their beef was the premise of the entire cartoon series. The infamous cat-and-mouse chase went on for decades, usually with Tom on the receiving end of the damage. Sometimes they fought over food, and other times they would go at it just because it was Tuesday. Of course, Jerry had a bit of an unfair advantage having Spike the bulldog on his side.